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Chiral Lewis acid-catalyzed enantioselective cyclopropanation and C–H insertion reactions of vinyl ketones with α-diazoesters

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Abstract

Enantioselective cyclopropanation and C–H insertion reactions of α-substituted vinyl ketones with α-diazoesters have been accomplished using a N,N′-dioxide-scandium(III) complex catalyst. Various tetrasubstituted cyclopropanes and E-enone derivatives bearing a chiral ester substituent were obtained simultaneously with good yields and excellent enantioselectivities.

Graphical abstract: Chiral Lewis acid-catalyzed enantioselective cyclopropanation and C–H insertion reactions of vinyl ketones with α-diazoesters

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Publication details

The article was received on 05 Jul 2018, accepted on 09 Aug 2018 and first published on 10 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05420G
Citation: Chem. Commun., 2018, Advance Article
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    Chiral Lewis acid-catalyzed enantioselective cyclopropanation and C–H insertion reactions of vinyl ketones with α-diazoesters

    P. Zhao, S. Wu, C. Ke, X. Liu and X. Feng, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC05420G

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