SCHEDULED MAINTENANCE
Approaching single DNA molecule detection with an ultrasensitive electrochemical genosensor based on gold nanoparticles and cobalt-porphyrin DNA conjugates†
Balwinder
Kaur, 
‡a
Kamila
Malecka,
‡a
Domenico A.
Cristaldi,
‡b
Clarissa S.
Chay,
‡b
Iwona
Mames,
‡b
Hanna
Radecka,
a
Jerzy
Radecki
*a
and
Eugen
Stulz
*b
‡a
Kamila
Malecka,
‡a
Domenico A.
Cristaldi,
‡b
Clarissa S.
Chay,
‡b
Iwona
Mames,
‡b
Hanna
Radecka,
a
Jerzy
Radecki
*a
and
Eugen
Stulz
*b
Abstract
We describe an ultrasensitive electrochemical genosensor based on gold nanoparticles and cobalt-porphyrin functionalised ssDNA probes. The sensitivity at the attomolar concentration level arises from an increased density of redox labels on the electrode surface compared to sensors without NP modification. The electrode detects as few as 23 DNA molecules, approaching single molecule detection.
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