Issue 63, 2018
From the journal:

Chemical Communications

Novel D–A–D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease†

Yuying Li,a   Kan Wang,b   Kaixiang Zhou,a   Wentao Guo, ORCID logo a   Bin Dai, ORCID logo b   Yi Liang, ORCID logo *b   Jiapei Daic  and  Mengchao Cui ORCID logo *a  

* Corresponding authors

a Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China
E-mail: cmc@bnu.edu.cn

b State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
E-mail: liangyi@whu.edu.cn

c Wuhan Institute for Neuroscience and Neuroengineering, South-Central University for Nationalities, Wuhan 430074, China

Abstract

Novel D–π–A–π–D probes were investigated for the detection of Aβ plaques and NFTs. The probes displayed remarkable optical properties, and DADNIR-2 possessed high affinity towards Tau and Aβ aggregates (Kd = 0.41 nM and 1.04 nM, respectively) with certain selectivity. DADNIR-2 could penetrate the BBB and label Aβ plaques in vivo.

Graphical abstract: Novel D–A–D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease

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Article information

DOI
https://doi.org/10.1039/C8CC05259J
Article type
Communication
Submitted
30 Jun 2018
Accepted
09 Jul 2018
First published
12 Jul 2018

Chem. Commun., 2018,54, 8717-8720

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Novel D–A–D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease

Y. Li, K. Wang, K. Zhou, W. Guo, B. Dai, Y. Liang, J. Dai and M. Cui, Chem. Commun., 2018, 54, 8717 DOI: 10.1039/C8CC05259J

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