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Issue 68, 2018
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A cytotoxic tantalum(V) half-sandwich complex: a new challenge for metal-based anticancer agents

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Abstract

Despite the biological relevance of complexes of various transition metals, tantalum complexes have long been neglected by bioinorganic chemists. Herein, we demonstrate potential chemotherapeutic applicability of the [Ta(η5-Cp*)Cl2(salaph)] (1) complex, containing deprotonated Schiff base 2-{(E)-[(2-hydroxyphenyl)imino]methyl}phenol (H2salaph), which shows strong cytotoxicity in cancer cells, related to the induction of apoptosis and apoptosis-related processes, but shows low cytotoxicity in healthy cells.

Graphical abstract: A cytotoxic tantalum(v) half-sandwich complex: a new challenge for metal-based anticancer agents

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Publication details

The article was received on 29 Jun 2018, accepted on 01 Aug 2018 and first published on 01 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05223A
Citation: Chem. Commun., 2018,54, 9533-9536
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    A cytotoxic tantalum(V) half-sandwich complex: a new challenge for metal-based anticancer agents

    P. Štarha, Z. Trávníček and Z. Dvořák, Chem. Commun., 2018, 54, 9533
    DOI: 10.1039/C8CC05223A

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