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A light-triggered transmembrane porin

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Abstract

Porins are ideal model systems for channel engineering. OmpG is a robust, monomeric, transmembrane β-barrel without ion selectivity. Here, we present a photocaged diethylaminocoumarin (DEACM) hybrid of OmpG. Blockage of the pore by DEACM is confirmed by reduced conductivity. An optimal effect was obtained when two bulky butyl-substituted coumarin cages were attached on the inside of the pore. Irradiation at 385 nm removed the photocages, leading to a restoration of channel conductivity.

Graphical abstract: A light-triggered transmembrane porin

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Publication details

The article was received on 29 Jun 2018, accepted on 06 Aug 2018 and first published on 06 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05221B
Citation: Chem. Commun., 2018, Advance Article
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    A light-triggered transmembrane porin

    J. Kahlstatt, P. Reiß, T. Halbritter, L.-O. Essen, U. Koert and A. Heckel, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC05221B

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