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Ruthenium(II)-catalyzed selective C–H difluoroalkylation of aniline derivatives with pyrimidyl auxiliaries

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Abstract

A ruthenium-catalyzed alternative para- and meta-difluoroalkylation of anilines is herein reported. The reaction tolerates a broad range of aniline derivatives and provides a convenient approach for accessing the corresponding para/meta-selective difluoroalkylated products. Mechanism studies demonstrated that the initial CAr–H and N–H cycloruthenation is the pivotal step in achieving remote C–H difluoroacetylation.

Graphical abstract: Ruthenium(ii)-catalyzed selective C–H difluoroalkylation of aniline derivatives with pyrimidyl auxiliaries

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Publication details

The article was received on 25 Jun 2018, accepted on 02 Aug 2018 and first published on 02 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05067H
Citation: Chem. Commun., 2018, Advance Article
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    Ruthenium(II)-catalyzed selective C–H difluoroalkylation of aniline derivatives with pyrimidyl auxiliaries

    X. Wang, Y. Li, L. Zhang, B. Zhang, Q. Wang, J. Ma and Y. Liang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC05067H

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