Issue 73, 2018
From the journal:

Chemical Communications

Development and cellular application of visible-light-controllable HNO releasers based on caged Piloty's acid†

Mitsuyasu Kawaguchi,a   Takuma Tani,a   Ryoma Hombu,a   Naoya Iedaa  and  Hidehiko Nakagawa ORCID logo *a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan
E-mail: deco@phar.nagoya-cu.ac.jp

Abstract

Nitroxyl (HNO) is a gaseous molecule with unique pharmacological functions distinct from those of nitric oxide. Because HNO is highly reactive with biological molecules, spatiotemporally controllable HNO releasers are required. Herein, we report the first visible-light-controllable HNO releasers, based on caged Piloty's acid, and we demonstrate their applicability in living cells.

Graphical abstract: Development and cellular application of visible-light-controllable HNO releasers based on caged Piloty's acid

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Article information

DOI
https://doi.org/10.1039/C8CC04954H
Article type
Communication
Submitted
21 Jun 2018
Accepted
17 Jul 2018
First published
28 Aug 2018
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2018,54, 10371-10374

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Development and cellular application of visible-light-controllable HNO releasers based on caged Piloty's acid

M. Kawaguchi, T. Tani, R. Hombu, N. Ieda and H. Nakagawa, Chem. Commun., 2018, 54, 10371 DOI: 10.1039/C8CC04954H

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