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Csp3–H bond functionalization of amines via tunable iminium ions: divergent synthesis of trifluoromethylated arylamines

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Abstract

A series of tunable iminium ions, generated in situ by the condensation of 4-trifluoromethyl-p-quinols with cyclic amines, can lead to the divergent synthesis of trifluoromethylated arylamines in a single step via redox-neutral isomerization. The direct α- and β-functionalization of saturated amines can be achieved regioselectively under mild conditions.

Graphical abstract: Csp3–H bond functionalization of amines via tunable iminium ions: divergent synthesis of trifluoromethylated arylamines

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Publication details

The article was received on 20 Jun 2018, accepted on 12 Jul 2018 and first published on 12 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04936J
Citation: Chem. Commun., 2018, Advance Article
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    Csp3–H bond functionalization of amines via tunable iminium ions: divergent synthesis of trifluoromethylated arylamines

    L. Shi, M. Wang, L. Pan, Y. Li and Q. Liu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC04936J

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