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Development of a novel inducer of protein–protein interactions based on aplyronine A

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Abstract

An aplyronine A–swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities. The hybrid retained strong cytotoxicity and actin-depolymerizing activity. In addition, the hybrid induced protein–protein interactions (PPI) between actin and tubulin in the manner of aplyronine A.

Graphical abstract: Development of a novel inducer of protein–protein interactions based on aplyronine A

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Publication details

The article was received on 09 Jun 2018, accepted on 04 Aug 2018 and first published on 06 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC04613A
Citation: Chem. Commun., 2018, Advance Article
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    Development of a novel inducer of protein–protein interactions based on aplyronine A

    T. Ohyoshi, A. Takano, M. Namiki, T. Ogura, Y. Miyazaki, Y. Ebihara, K. Takeno, I. Hayakawa and H. Kigoshi, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC04613A

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