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Insights into beta-ketoacyl-chain recognition for beta-ketoacyl-ACP utilizing AHL synthases

Abstract

Beta-ketoacyl-ACP utilizing enzymes in fatty acid, polyketide and acyl-homoserine lactone biosynthetic pathways are important targets for developing antimicrobial, anticancer and antiparastic compounds. Published reports on successful isolation of beta-ketoacyl-ACPs in a laboratory remain scarce to date and thus most beta-ketoacyl-ACP utilizing enzymes are routinely characterized using small molecule substrates in lieu of the bonafide 3-oxoacyl-ACPs. We report the systematic investigation into the electronic, geometric and spatial aspects of beta-ketoacyl-chain recognition to develop 3-oxoacyl-ACP substrate mimics for two beta-ketoacyl-ACP utilizing quorum signal synthases.

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Publication details

The article was received on 06 Jun 2018, accepted on 11 Jul 2018 and first published on 13 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04532A
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Insights into beta-ketoacyl-chain recognition for beta-ketoacyl-ACP utilizing AHL synthases

    M. Nhu Lam, D. Dudekula, B. Durham, N. Collingwood, E. Brown and R. Nagarajan, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC04532A

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