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Issue 65, 2018
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Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

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Abstract

Substrate binding assays, in vitro proteolytic processing assays, and heterologous lasso peptide production were used to investigate the roles of conserved precursor peptide residues during paeninodin maturation. Specifically, we delineate which residues are important for substrate recognition, proteolysis, and lasso peptide macrocyclization.

Graphical abstract: Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

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Publication details

The article was received on 01 Jun 2018, accepted on 20 Jul 2018 and first published on 20 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04411B
Citation: Chem. Commun., 2018,54, 9007-9010
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    Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

    J. D. Hegemann, C. J. Schwalen, D. A. Mitchell and W. A. van der Donk, Chem. Commun., 2018, 54, 9007
    DOI: 10.1039/C8CC04411B

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