Iodine catalyzed reduction of quinolines under mild reaction conditions

Abstract

A reduction of quinolines to synthetically versatile tetrahydroquinoline molecules with I₂ and HBpin is described. In the presence of iodine (20 mol%) as a catalyst, reduction of quinolines and other N-heteroarenes proceeded readily with hydroboranes as the reducing reagents. The broad functional-group tolerance, good yields and mild reaction conditions imply high practical utility.