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Target discovery of ebselen with a biotinylated probe

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Abstract

Despite numerous studies on ebselen over the past decade, its cellular targets remain obscure. Here we synthesized a biotinylated ebselen probe (biotin-ebselen) and characterized ebselen-binding proteins via an efficient activity-based protein profiling (ABPP) method, which allowed for the robust identification of 462 targeted proteins in HeLa cells. This first work of global target profiling of ebselen will be helpful to re-design ebselen-based therapy appropriately in clinical trials.

Graphical abstract: Target discovery of ebselen with a biotinylated probe

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Publication details

The article was received on 29 May 2018, accepted on 30 Jul 2018 and first published on 31 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04258F
Citation: Chem. Commun., 2018, Advance Article
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    Target discovery of ebselen with a biotinylated probe

    Z. Chen, Z. Jiang, N. Chen, Q. Shi, L. Tong, F. Kong, X. Cheng, H. Chen, C. Wang and B. Tang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC04258F

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