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Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent

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Abstract

Hybrid molecules have been developed which are comprised of a tyrosine kinase-targeted, quinazoline-based scaffold and a flexibly linked dia(m)minechloridoPt(II) moiety. The target compounds maintain high affinity and selectivity for ErbB family kinase proteins and one of the derivatives induces platinum adducts with a pharmacologically important cysteine residue.

Graphical abstract: Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent

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Publication details

The article was received on 29 May 2018, accepted on 11 Jun 2018 and first published on 12 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC04251A
Citation: Chem. Commun., 2018, Advance Article
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    Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent

    M. Yang, H. Wu, J. Chu, L. A. Gabriel, Y. Kim, K. S. Anderson, C. M. Furdui and U. Bierbach, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC04251A

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