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Issue 65, 2018
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Transfer hydrogenative para-selective aminoalkylation of aniline derivatives with N-heteroarenes via ruthenium/acid dual catalysis

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Abstract

By ruthenium/acid dual catalysis, we present, for the first time, a transfer hydrogenative para-selective aminoalkylation of aniline derivatives with N-heteroarenes. Position-2 of the sterically less-hindered pyridine ring of the N-heteroarenes couples with various aniline derivatives at the site para to the amino group, affording a wide array of structurally modified anilines, a class of highly valuable compounds with the potential for discovery and further creation of functional molecules. The developed chemistry features operational simplicity, a readily available catalyst system, excellent functional group tolerance, and exclusive regioselectivity, which offers a significant basis to access novel aniline derivatives that are currently inaccessible or challenging to prepare with conventional approaches, and design new coupling reactions via a hydrogen transfer strategy.

Graphical abstract: Transfer hydrogenative para-selective aminoalkylation of aniline derivatives with N-heteroarenes via ruthenium/acid dual catalysis

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Publication details

The article was received on 28 May 2018, accepted on 20 Jul 2018 and first published on 23 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04233K
Citation: Chem. Commun., 2018,54, 9087-9090
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    Transfer hydrogenative para-selective aminoalkylation of aniline derivatives with N-heteroarenes via ruthenium/acid dual catalysis

    X. Chen, H. Zhao, C. Chen, H. Jiang and M. Zhang, Chem. Commun., 2018, 54, 9087
    DOI: 10.1039/C8CC04233K

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