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Issue 65, 2018
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A catalytic N-deacylative alkylation approach to hexahydropyrrolo[2,3-b]indole alkaloids

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Abstract

A versatile unprecedented strategy to diversely functionalized hexahydropyrrolo[2,3-b]indole alkaloids is described in high chemical yields. The synthesis features a key Pd(0)-catalyzed deacylative alkylation of N-acyl 3-substituted indoles using only 1 mol% of Pd(PPh3)4. The scope of this methodology is further defined in the asymmetric synthesis of pyrroloindolines using a diastereoselective approach.

Graphical abstract: A catalytic N-deacylative alkylation approach to hexahydropyrrolo[2,3-b]indole alkaloids

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Publication details

The article was received on 23 May 2018, accepted on 21 Jul 2018 and first published on 23 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04117B
Citation: Chem. Commun., 2018,54, 9083-9086
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    A catalytic N-deacylative alkylation approach to hexahydropyrrolo[2,3-b]indole alkaloids

    N. Kumar, A. Maity, V. R. Gavit and A. Bisai, Chem. Commun., 2018, 54, 9083
    DOI: 10.1039/C8CC04117B

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