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Issue 57, 2018
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Ultra-sensitive fluorescent probes for hypochlorite acid detection and exogenous/endogenous imaging of living cells

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Abstract

Two fluorescent probes (Naph-1 and Naph-2), which can be prepared via a facile process, have been developed to detect hypochlorite acid (HOCl). The N,N-dimethyl thiocarbamate group quenches the fluorescence of the probes through intramolecular charge transfer (ICT). Upon reaction with HOCl in aqueous buffer, Naph-1 shows ultra-high sensitivity towards HOCl through a 4600-fold increase in fluorescence intensity, as well as a detection limit of 2.37 nM. The probes have been applied to confocal fluorescence imaging of exogenous and endogenous HOCl in living cells.

Graphical abstract: Ultra-sensitive fluorescent probes for hypochlorite acid detection and exogenous/endogenous imaging of living cells

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Publication details

The article was received on 17 May 2018, accepted on 20 Jun 2018 and first published on 20 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC03963A
Citation: Chem. Commun., 2018,54, 7967-7970
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    Ultra-sensitive fluorescent probes for hypochlorite acid detection and exogenous/endogenous imaging of living cells

    Y. Jiang, G. Zheng, Q. Duan, L. Yang, J. Zhang, H. Zhang, J. He, H. Sun and D. Ho, Chem. Commun., 2018, 54, 7967
    DOI: 10.1039/C8CC03963A

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