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Issue 65, 2018
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Synthetic approaches to construct viral capsid-like spherical nanomaterials

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Abstract

This feature article describes recent progress in synthetic strategies to construct viral capsid-like spherical nanomaterials using the self-assembly of peptides and/or proteins. By mimicking the self-assembly of spherical viral capsids and clathrin, trigonal peptide conjugates bearing β-sheet-forming peptides, glutathiones, or coiled-coil-forming peptides were developed to construct viral capsid-like particles. β-Annulus peptides from tomato bushy stunt virus self-assembled into viral capsid-like nanocapsules with a size of 30–50 nm, which could encapsulate various guest molecules and be decorated with different molecules on their surface. Rationally designed fusion proteins bearing symmetric assembling units afforded precise viral capsid-like polyhedral assemblies. These synthetic approaches to construct artificial viruses could become useful guidelines to develop novel drug carriers, vaccine platforms, nanotemplates and nanoreactors.

Graphical abstract: Synthetic approaches to construct viral capsid-like spherical nanomaterials

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Publication details

The article was received on 14 May 2018, accepted on 31 May 2018 and first published on 31 May 2018


Article type: Feature Article
DOI: 10.1039/C8CC03844A
Citation: Chem. Commun., 2018,54, 8944-8959
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    Synthetic approaches to construct viral capsid-like spherical nanomaterials

    K. Matsuura, Chem. Commun., 2018, 54, 8944
    DOI: 10.1039/C8CC03844A

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