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Issue 57, 2018
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Substrate-controlled divergent synthesis of polycyclic indoloazepines and indolodiazepines via 1,5-hydride shift/7-cyclization cascades

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Abstract

Novel and practical acid-catalyzed cyclization of 2-indolyl aryl carbinols via tandem dehydration/1,5-hydride shift/7-cyclization sequences has been developed. By appropriate variation of the substrate, diverse polycyclic-fused indoles were synthesized in good yield, thus demonstrating the high efficiency, transition-metal-free nature, and high step/atom economy of the synthesis strategy.

Graphical abstract: Substrate-controlled divergent synthesis of polycyclic indoloazepines and indolodiazepines via 1,5-hydride shift/7-cyclization cascades

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Publication details

The article was received on 11 May 2018, accepted on 15 Jun 2018 and first published on 16 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC03804J
Citation: Chem. Commun., 2018,54, 7928-7931
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    Substrate-controlled divergent synthesis of polycyclic indoloazepines and indolodiazepines via 1,5-hydride shift/7-cyclization cascades

    S. Liu, J. Qu and B. Wang, Chem. Commun., 2018, 54, 7928
    DOI: 10.1039/C8CC03804J

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