Issue 49, 2018

Highly enantioselective Friedel–Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal–organic framework

Abstract

The first enantioselective Friedel–Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal–organic framework constructed from (R)-2,2′-dihydroxy-1,1′-binaphthyl-6,6′-dicarboxylic acid has been developed. The reaction proceeded in high yields (∼96%) with excellent enantioselectivities (∼98% ee).

Graphical abstract: Highly enantioselective Friedel–Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal–organic framework

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2018
Accepted
24 May 2018
First published
25 May 2018

Chem. Commun., 2018,54, 6328-6331

Highly enantioselective Friedel–Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal–organic framework

K. Tanaka, K. Sakuragi, H. Ozaki and Y. Takada, Chem. Commun., 2018, 54, 6328 DOI: 10.1039/C8CC03447H

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