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Issue 48, 2018
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Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies

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Abstract

The first systematic investigation of the effect of high mannose, hybrid, and bi- and tri-antennary complex type glycans on the effector functions of antibodies was achieved by the discovery of novel Endo-S2 mutants generated by site-directed mutagenesis as glycosynthases with broad substrate specificity.

Graphical abstract: Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies

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Publication details

The article was received on 30 Apr 2018, accepted on 21 May 2018 and first published on 29 May 2018


Article type: Communication
DOI: 10.1039/C8CC03384F
Citation: Chem. Commun., 2018,54, 6161-6164
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    Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies

    S. S. Shivatare, L. Huang, Y. Zeng, J. Liao, T. You, S. Wang, T. Cheng, C. Chiu, P. Chao, L. Chen, T. Tsai, C. Huang, C. Wu, N. Lin and C. Wong, Chem. Commun., 2018, 54, 6161
    DOI: 10.1039/C8CC03384F

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