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Mild rhodium(III)-catalyzed intramolecular annulation of benzamides with allylic alcohols to access azepinone derivatives

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Abstract

Azepinone derivatives are important frameworks of several natural products and bioactive compounds. They are synthetized using a Rh(III)-catalyzed intramolecular annulation of benzamide-tethered allylic alcohols. The reaction requires mild conditions at room temperature and affords diversely substituted azepinones bearing a quaternary carbon.

Graphical abstract: Mild rhodium(iii)-catalyzed intramolecular annulation of benzamides with allylic alcohols to access azepinone derivatives

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Publication details

The article was received on 24 Apr 2018, accepted on 16 May 2018 and first published on 16 May 2018


Article type: Communication
DOI: 10.1039/C8CC03319F
Citation: Chem. Commun., 2018, Advance Article
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    Mild rhodium(III)-catalyzed intramolecular annulation of benzamides with allylic alcohols to access azepinone derivatives

    A. Peneau, Q. Tricart, C. Guillou and L. Chabaud, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC03319F

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