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In vivo imaging of hepatocellular nitric oxide using a hepatocyte-targeting fluorescent sensor

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Abstract

Imaging of hepatocellular nitric oxide (NO) in vivo is of great importance for understanding its roles in liver diseases, but such an imaging approach is still lacking. Herein, a hepatocyte-targeting fluorescent NO sensor has been fabricated. This sensor exhibits good water solubility, excellent selectivity, and high sensitivity (∼1.62 nM). The cells and in vivo imaging experiments reveal that Gal-RhB facilitates the visualization of hepatocellular NO in both HepG2 cells and zebrafish. These results demonstrate that Gal-RhB may be a promising tool for studying the function of NO in NO-associated liver diseases.

Graphical abstract: In vivo imaging of hepatocellular nitric oxide using a hepatocyte-targeting fluorescent sensor

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Publication details

The article was received on 22 Apr 2018, accepted on 05 Jun 2018 and first published on 05 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC03240H
Citation: Chem. Commun., 2018, Advance Article
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    In vivo imaging of hepatocellular nitric oxide using a hepatocyte-targeting fluorescent sensor

    P. Zhang, Y. Tian, H. Liu, J. Ren, H. Wang, R. Zeng, Y. Long and J. Chen, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC03240H

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