Jump to main content
Jump to site search

Issue 49, 2018
Previous Article Next Article

Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers

Author affiliations

Abstract

Herein we report that a preferable inhibition of the nucleation phase of Aβ42, related to the formation of toxic oligomers, by triterpenoids from medicinal herbs originates from a salt bridge of their carboxy groups with Lys16 and 28 in Aβ42. Such a direct interaction targeting the monomer, dimer, and trimer suppressed further oligomerization. In contrast, the corresponding congeners without carboxy groups failed to do so.

Graphical abstract: Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Apr 2018, accepted on 22 May 2018 and first published on 23 May 2018


Article type: Communication
DOI: 10.1039/C8CC03230K
Citation: Chem. Commun., 2018,54, 6272-6275
  •   Request permissions

    Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers

    K. Murakami, T. Yoshioka, S. Horii, M. Hanaki, S. Midorikawa, S. Taniwaki, H. Gunji, K. Akagi, T. Kawase, K. Hirose and K. Irie, Chem. Commun., 2018, 54, 6272
    DOI: 10.1039/C8CC03230K

Search articles by author

Spotlight

Advertisements