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Issue 48, 2018
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Transition-metal-free insertion reactions of alkynes into the C–N σ-bonds of imides: synthesis of substituted enamides or chromones

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Abstract

A transition-metal-free tandem process for the synthesis of substituted enamides and chromones is presented. The insertion of isolated alkynes into the C–N σ-bonds of imides is involved in this tandem process. In the case of alkynones bearing an ortho-bromo-substituted aryl ring, chromones were selectively formed via the O-cyclization pathway. A variety of substituted enamides and chromones were prepared in good to high yields.

Graphical abstract: Transition-metal-free insertion reactions of alkynes into the C–N σ-bonds of imides: synthesis of substituted enamides or chromones

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Publication details

The article was received on 17 Apr 2018, accepted on 19 May 2018 and first published on 23 May 2018


Article type: Communication
DOI: 10.1039/C8CC03059F
Citation: Chem. Commun., 2018,54, 6192-6195
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    Transition-metal-free insertion reactions of alkynes into the C–N σ-bonds of imides: synthesis of substituted enamides or chromones

    Z. Zheng, Y. Wang, M. Xu, L. Kong, M. Wang and Y. Li, Chem. Commun., 2018, 54, 6192
    DOI: 10.1039/C8CC03059F

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