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Issue 56, 2018
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Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

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Abstract

Oligomeric and protofibrillar aggregates that are populated along the pathway of amyloid fibril formation appear generally to be more toxic than the mature fibrillar state. In particular, α-synuclein, the protein associated with Parkinson's disease, forms kinetically trapped protofibrils in the presence of lipid vesicles. Here, we show that lipid-induced α-synuclein protofibrils can convert rapidly to mature fibrils at higher temperatures. Furthermore, we find that β-synuclein, generally considered less aggregation prone than α-synuclein, forms protofibrils at higher temperatures. These findings highlight the importance of energy barriers in controlling the de novo formation and conversion of amyloid fibrils.

Graphical abstract: Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

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Publication details

The article was received on 16 Apr 2018, accepted on 12 Jun 2018 and first published on 28 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC03002B
Citation: Chem. Commun., 2018,54, 7854-7857
  • Open access: Creative Commons BY-NC license
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    Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

    J. W. P. Brown, G. Meisl, T. P. J. Knowles, A. K. Buell, C. M. Dobson and C. Galvagnion, Chem. Commun., 2018, 54, 7854
    DOI: 10.1039/C8CC03002B

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