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Issue 49, 2018
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A mitochondria-targeting hetero-binuclear Ir(III)–Pt(II) complex induces necrosis in cisplatin-resistant tumor cells

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Abstract

A hetero-binuclear Ir(III)–Pt(II) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.

Graphical abstract: A mitochondria-targeting hetero-binuclear Ir(iii)–Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells

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Publication details

The article was received on 08 Apr 2018, accepted on 25 May 2018 and first published on 25 May 2018


Article type: Communication
DOI: 10.1039/C8CC02795A
Citation: Chem. Commun., 2018,54, 6268-6271
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    A mitochondria-targeting hetero-binuclear Ir(III)–Pt(II) complex induces necrosis in cisplatin-resistant tumor cells

    C. Ouyang, L. Chen, T. W. Rees, Y. Chen, J. Liu, L. Ji, J. Long and H. Chao, Chem. Commun., 2018, 54, 6268
    DOI: 10.1039/C8CC02795A

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