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Issue 57, 2018
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Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry

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Abstract

Understanding of amyloid aggregation in terms of thermodynamics and kinetics is still limited. We herein examined the mechanism of β2-microglobulin amyloidogenesis using our unique method of isothermal titration calorimetry-based thermodynamic/kinetic measurements, and revealed the energy landscape of polymorphic amyloidogenesis under biological environment-mimicking conditions including shear forces and crowding effects.

Graphical abstract: Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry

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Publication details

The article was received on 04 Apr 2018, accepted on 26 Jun 2018 and first published on 27 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC02718H
Citation: Chem. Commun., 2018,54, 7995-7998
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    Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry

    M. Kinoshita, Y. Lin, I. Dai, M. Okumura, N. Markova, J. E. Ladbury, F. Sterpone and Y. Lee, Chem. Commun., 2018, 54, 7995
    DOI: 10.1039/C8CC02718H

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