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Issue 48, 2018
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Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein–Ru(carbene) adduct

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Abstract

The first X-ray structures of adducts formed between a RuII(N-heterocyclic carbene)(η6-p-cymene) compound and a protein are reported. Coordination to the protein induced the cleavage of the cymene ligand and EPR spectroscopy demonstrated the oxidation of the Ru centre.

Graphical abstract: Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein–Ru(carbene) adduct

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Publication details

The article was received on 27 Mar 2018, accepted on 23 Apr 2018 and first published on 23 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC02433B
Citation: Chem. Commun., 2018,54, 6120-6123
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    Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein–Ru(carbene) adduct

    M. P. Sullivan, M. K. Nieuwoudt, G. A. Bowmaker, N. Y. S. Lam, D. Truong, D. C. Goldstone and C. G. Hartinger, Chem. Commun., 2018, 54, 6120
    DOI: 10.1039/C8CC02433B

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