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Issue 48, 2018
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Optochemical control of gene expression by photocaged guanine and riboswitches

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Abstract

Optical control of biomolecules via engineered proteins or photoactive small molecules has had a profound impact on biology. However, optochemical tools to control RNA functions in living cells are relatively limited. We synthesized a photoactivatable (photocaged) guanine to modulate gene expression under riboswitch control in both mammalian cells and Escherichia coli by light.

Graphical abstract: Optochemical control of gene expression by photocaged guanine and riboswitches

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Publication details

The article was received on 22 Mar 2018, accepted on 18 May 2018 and first published on 30 May 2018


Article type: Communication
DOI: 10.1039/C8CC02290A
Citation: Chem. Commun., 2018,54, 6181-6183
  • Open access: Creative Commons BY-NC license
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    Optochemical control of gene expression by photocaged guanine and riboswitches

    V. Dhamodharan, Y. Nomura, M. Dwidar and Y. Yokobayashi, Chem. Commun., 2018, 54, 6181
    DOI: 10.1039/C8CC02290A

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