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Issue 65, 2018
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A ruthenium–platinum metal complex that binds to sarcin ricin loop RNA and lowers mRNA expression

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Abstract

IT127 is a dinuclear transition metal complex that contains a Pt(II) and a Ru(III) metal center. We have shown that IT127 is significantly more effective in binding the 29-base sarcin ricin loop (SRL) RNA in comparison to Cisplatin, a hallmark anticancer agent. Binding site analysis shows that IT127 prefers purine bases and the GAGA tetraloop region of SRL RNA. Our results with a dihydrofolate reductase (DHFR) model system reveal that IT127 binding to mRNA reduces translation of DHFR enzyme and that the Ru(III) and Pt(II) centers in IT127 appear to work in a synergistic manner.

Graphical abstract: A ruthenium–platinum metal complex that binds to sarcin ricin loop RNA and lowers mRNA expression

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Publication details

The article was received on 19 Mar 2018, accepted on 18 Jun 2018 and first published on 20 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC02131G
Citation: Chem. Commun., 2018,54, 8987-8990
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    A ruthenium–platinum metal complex that binds to sarcin ricin loop RNA and lowers mRNA expression

    S. S. Jain, C. M. Anderson, I. A. Sapse, S. H. Lundgren, A. K. Freer, H. Hoang, K. Jain and M. Breshears, Chem. Commun., 2018, 54, 8987
    DOI: 10.1039/C8CC02131G

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