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Issue 49, 2018
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Lipid-exchange in nanodiscs discloses membrane boundaries of cytochrome-P450 reductase

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Abstract

Lipids are critical for the function of membrane proteins. NADPH–cytochrome-P450-reductase, the sole electron transferase for microsomal oxygenases, possesses a conformational dynamics entwined with its topology. Here, we use peptide-nanodiscs to unveil cytochrome-P450-reductase's lipid boundaries, demonstrating a protein-driven enrichment of ethanolamine lipids (by 25%) which ameliorates by 3-fold CPR's electron-transfer ability.

Graphical abstract: Lipid-exchange in nanodiscs discloses membrane boundaries of cytochrome-P450 reductase

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Publication details

The article was received on 12 Mar 2018, accepted on 30 May 2018 and first published on 30 May 2018


Article type: Communication
DOI: 10.1039/C8CC02003E
Citation: Chem. Commun., 2018,54, 6336-6339
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    Lipid-exchange in nanodiscs discloses membrane boundaries of cytochrome-P450 reductase

    C. Barnaba, T. Ravula, I. G. Medina-Meza, S. Im, G. M. Anantharamaiah, L. Waskell and A. Ramamoorthy, Chem. Commun., 2018, 54, 6336
    DOI: 10.1039/C8CC02003E

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