Jump to main content
Jump to site search


Redox-responsive cisplatin nanogels for anticancer drug delivery

Author affiliations

Abstract

Inspired by cisplatin's deactivation by glutathione (GSH) in cancer, a GSH responsive nanogel loaded with doxorubicin (Dox) was prepared using hyaluronan as a matrix and cisplatin as a crosslinker. The elevated GSH depletes the cisplatin crosslinker in the nanogel, enhances Dox release and boosts cytotoxicity, thus providing a new GSH responsive platform to reverse cisplatin resistance.

Graphical abstract: Redox-responsive cisplatin nanogels for anticancer drug delivery

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Mar 2018, accepted on 02 Jul 2018 and first published on 03 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC01795F
Citation: Chem. Commun., 2018, Advance Article
  •   Request permissions

    Redox-responsive cisplatin nanogels for anticancer drug delivery

    W. Zhang and C. Tung, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC01795F

Search articles by author

Spotlight

Advertisements