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Issue 49, 2018
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Redox-triggered intracellular siRNA delivery

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Abstract

Gene silencing using small interfering RNA (siRNA) is a promising strategy for the treatment of multiple diseases. However, the low in vivo stability of siRNA, its poor pharmacokinetics and inability to penetrate inside cells limit its employment in the clinic. Here, we present a novel redox-sensitive micellar nanopreparation based on a triple conjugate of polyethylene glycol, polyethyleneimine and phosphatidylethanolamine, PEG-SS-PEI-PE (PSSPD). This non-toxic system efficiently condenses siRNA and specifically downregulates target green fluorescent protein (GFP) only under reducing conditions via intracellular siRNA release after de-shielding of PEG due to increased glutathione (GSH) levels characteristic of cancer cells.

Graphical abstract: Redox-triggered intracellular siRNA delivery

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Supplementary files

Publication details

The article was received on 16 Feb 2018, accepted on 28 May 2018 and first published on 28 May 2018


Article type: Communication
DOI: 10.1039/C8CC01376D
Citation: Chem. Commun., 2018,54, 6368-6371
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    Redox-triggered intracellular siRNA delivery

    N. B. Mutlu Agardan, C. Sarisozen and V. P. Torchilin, Chem. Commun., 2018, 54, 6368
    DOI: 10.1039/C8CC01376D

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