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Issue 57, 2018
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Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions

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Abstract

The on-column functionalization of oligodeoxynucleotides via base-free Suzuki cross-coupling reactions is reported herein. These cross-coupling reactions were carried out with various boronic acids and either full-length modified oligonucleotides containing one or more 2′-deoxy-5-iodouridine (5IdU) monomer(s) or on oligonucleotide fragments immediately after incorporation of 5IdU. Five different functionalities were coupled to oligonucleotides containing one or three attachment points.

Graphical abstract: Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions

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Publication details

The article was received on 16 Feb 2018, accepted on 22 Jun 2018 and first published on 25 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC01360H
Citation: Chem. Commun., 2018,54, 8003-8006
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    Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions

    M. Ejlersen, C. Lou, Y. S. Sanghvi, Y. Tor and J. Wengel, Chem. Commun., 2018, 54, 8003
    DOI: 10.1039/C8CC01360H

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