Jump to main content
Jump to site search

Issue 41, 2018
Previous Article Next Article

Tuning conformation and properties of peptidomimetic backbones through dual N/Cα-substitution

Author affiliations

Abstract

We demonstrate that changing the backbone between peptides, peptoids and the underexplored dual N/Cα-substituted peptoids analogues allows for control over the preferred conformation of the intrinsically disordered biomimetic oligomers. The conformation tunability is directly probed using electron paramagnetic resonance (EPR), and is shown to manifest itself in differences in the nanoparticle–oligomer hybridization propensity.

Graphical abstract: Tuning conformation and properties of peptidomimetic backbones through dual N/Cα-substitution

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Feb 2018, accepted on 26 Apr 2018 and first published on 27 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC01356J
Citation: Chem. Commun., 2018,54, 5237-5240
  •   Request permissions

    Tuning conformation and properties of peptidomimetic backbones through dual N/Cα-substitution

    R. Kaminker, I. Kaminker, W. R. Gutekunst, Y. Luo, S. Lee, J. Niu, S. Han and C. J. Hawker, Chem. Commun., 2018, 54, 5237
    DOI: 10.1039/C8CC01356J

Search articles by author

Spotlight

Advertisements