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Issue 41, 2018
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Photoactivation of imatinib–antibody conjugate using low-energy visible light from Ru(II)-polypyridyl cages

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Abstract

Ru(II)-polypyridyl cages with sterically bulky bidentate ligands provide efficient photochemical release of the anticancer drug imatinib using low energy visible light, imparting spatiotemporal control over drug bioavailability. The light-activated drug release is maintained when the Ru(II) cage is covalently coupled to an antibody, which is expected to localize selectively on the tumor.

Graphical abstract: Photoactivation of imatinib–antibody conjugate using low-energy visible light from Ru(ii)-polypyridyl cages

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Publication details

The article was received on 15 Feb 2018, accepted on 23 Apr 2018 and first published on 30 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC01348A
Citation: Chem. Commun., 2018,54, 5193-5196
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    Photoactivation of imatinib–antibody conjugate using low-energy visible light from Ru(II)-polypyridyl cages

    T. N. Rohrabaugh, A. M. Rohrabaugh, J. J. Kodanko, J. K. White and C. Turro, Chem. Commun., 2018, 54, 5193
    DOI: 10.1039/C8CC01348A

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