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Inhibition of tau-derived hexapeptide aggregation and toxicity by a self-assembled cyclic D,L-α-peptide conformational inhibitor

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Abstract

Aggregation and accumulation of amyloid β and tau proteins to plaques and neurofibrillary tangles are the key pathogenic events in Alzheimer's disease. Here, we studied the capability of the cyclic D,L-α-peptide CP-2 as a conformational inhibitor of different amyloids to cross-interact with tau-derived AcPHF6 peptide and inhibit its aggregation, membrane perturbation and toxicity.

Graphical abstract: Inhibition of tau-derived hexapeptide aggregation and toxicity by a self-assembled cyclic d,l-α-peptide conformational inhibitor

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Publication details

The article was received on 11 Feb 2018, accepted on 14 May 2018 and first published on 16 May 2018


Article type: Communication
DOI: 10.1039/C8CC01233D
Citation: Chem. Commun., 2018, Advance Article
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    Inhibition of tau-derived hexapeptide aggregation and toxicity by a self-assembled cyclic D,L-α-peptide conformational inhibitor

    A. Belostozky, M. Richman, E. Lisniansky, A. Tovchygrechko, J. H. Chill and S. Rahimipour, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC01233D

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