Issue 32, 2018

A missing member of conjugated N-heterocycles: realizing pyrido[1,2-α]azepine by reacting ruthenium alkenylcarbene complex with alkyne

Abstract

Despite the excellent chemical properties of N-heterocycles, pyrido[1,2-α]azepine remains elusive due to its potential antiaromaticity and lability. Herein, we demonstrate the synthesis and characterization of the first bicyclic pyrido[1,2-α]azepine that leverages the coordination to the ruthenium center to promote the stability of N-bridged bicycle.

Graphical abstract: A missing member of conjugated N-heterocycles: realizing pyrido[1,2-α]azepine by reacting ruthenium alkenylcarbene complex with alkyne

Supplementary files

Article information

Article type
Communication
Submitted
29 Jan 2018
Accepted
20 Mar 2018
First published
21 Mar 2018

Chem. Commun., 2018,54, 4009-4012

A missing member of conjugated N-heterocycles: realizing pyrido[1,2-α]azepine by reacting ruthenium alkenylcarbene complex with alkyne

X. Zhou, F. Huang, C. Tang, Q. Zhuo, Z. Chen, H. Zhang and H. Xia, Chem. Commun., 2018, 54, 4009 DOI: 10.1039/C8CC00758F

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