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Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae

Abstract

This study established the comprehensive repeating unit structure of immunologically-active glucuronoxylomannan (AAPS) from wood ear mushroom, Auricularia auricula-judae. We identified Toll-like receptor 4 (TLR4) as a critical receptor involved in AAPS-induced macrophage activation to secrete pro-inflammatory cytokines. Molecular modeling data and chemical modifications of AAPS revealed that both carboxylic and acetyl moieties of AAPS are equally essential in TLR4 binding to exert in vitro immunostimulatory activity.

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Publication details

The article was received on 29 Dec 2017, accepted on 16 May 2018 and first published on 18 May 2018


Article type: Communication
DOI: 10.1039/C7CC09927D
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae

    N. Perera, F. Yang, J. Chern, H. Chiu, C. Hsieh, L. Li, Y. Zhang, K. Hua and S. Wu, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C7CC09927D

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