Issue 10, 2018

A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug delivery

Abstract

We studied the role of the additives trehalose and poly(vinyl pyrrolidone) in the physical and pharmacokinetic properties of peptide drug incorporated hyaluronic acid microneedles. Poly(vinyl pyrrolidone) increases the mechanical strength of microneedles and ameliorates drug bioavailability in vivo, suggesting that poly(vinyl pyrrolidone) can be a promising additive in the fabrication of peptide drug-encapsulated fully dissolving microneedles.

Graphical abstract: A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug delivery

Supplementary files

Article information

Article type
Communication
Submitted
06 Jul 2018
Accepted
28 Jul 2018
First published
07 Aug 2018

Biomater. Sci., 2018,6, 2566-2570

A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug delivery

H. K. Kim, S. H. Lee, B. Y. Lee, S. J. Kim, C. Y. Sung, N. K. Jang, J. D. Kim, D. H. Jeong, H. Y. Ryu and S. Lee, Biomater. Sci., 2018, 6, 2566 DOI: 10.1039/C8BM00768C

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