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Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell

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Abstract

This work reports the first images obtained by combining an infrared aperture scanning near-field optical microscope (SNOM) with a quantum cascade laser (QCL). The future potential of this set-up is demonstrated by a preliminary study on an OE33 human oesophageal adenocarcinoma cell in which the cell is imaged at 1751 cm−1, 1651 cm−1, 1539 cm−1 and 1242 cm−1. In addition to the 1651 cm−1 image, three other images were acquired within the Amide I band (1689 cm−1, 1675 cm−1 and 1626 cm−1) chosen to correspond to secondary structures of proteins. The four images obtained within the Amide I band show distinct differences demonstrating the potential of this approach to reveal subtle changes in the chemical composition of a cell.

Graphical abstract: Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell

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Publication details

The article was received on 27 Jun 2018, accepted on 31 Aug 2018 and first published on 31 Aug 2018


Article type: Communication
DOI: 10.1039/C8AN01183D
Citation: Analyst, 2018, Advance Article
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    Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell

    C. I. Smith, M. R. F. Siggel-King, J. Ingham, P. Harrison, D. S. Martin, A. Varro, D. M. Pritchard, M. Surman, S. Barrett and P. Weightman, Analyst, 2018, Advance Article , DOI: 10.1039/C8AN01183D

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