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Estimation of G-quartet-forming guanines in parallel-type G-quadruplexes by optical spectroscopy measurements of their single-nucleobase substitution sequences

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Abstract

Since much attention has been paid to in vivo biological functions of G-quadruplexes, structural analyses of G-quadruplexes are essential for understanding their functional mechanisms. Here, we established a simple optical-spectroscopy-based method for the estimation of G-quartet-forming guanines in parallel-type G-quadruplexes using measurements of circular dichroism and the thermal melting temperature.

Graphical abstract: Estimation of G-quartet-forming guanines in parallel-type G-quadruplexes by optical spectroscopy measurements of their single-nucleobase substitution sequences

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Publication details

The article was received on 20 Jun 2018, accepted on 18 Jul 2018 and first published on 30 Jul 2018


Article type: Communication
DOI: 10.1039/C8AN01131A
Citation: Analyst, 2018, Advance Article
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    Estimation of G-quartet-forming guanines in parallel-type G-quadruplexes by optical spectroscopy measurements of their single-nucleobase substitution sequences

    R. Maruyama, K. Makino, T. Yoshitomi, H. Yui, H. Furusho and K. Yoshimoto, Analyst, 2018, Advance Article , DOI: 10.1039/C8AN01131A

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