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Single-cell assay on microfluidic devices

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Abstract

Advances in microfluidic techniques have prompted researchers to study the inherent heterogeneity of single cells in cell populations. This would be helpful in the identification of major diseases and the design of personalized medicine. Different microfluidic approaches provide a variety of functions in the process of single-cell analysis. In this review, we take a broad overview of various microfluidic-based approaches for single-cell isolation, single-cell lysis, and single-cell analysis. Up-to-date flagship techniques and the pros and cons of these methods are discussed in detail.

Graphical abstract: Single-cell assay on microfluidic devices

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Publication details

The article was received on 12 Jun 2018, accepted on 22 Aug 2018 and first published on 22 Aug 2018


Article type: Critical Review
DOI: 10.1039/C8AN01079J
Citation: Analyst, 2018, Advance Article
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    Single-cell assay on microfluidic devices

    Q. Huang, S. Mao, M. Khan and J. Lin, Analyst, 2018, Advance Article , DOI: 10.1039/C8AN01079J

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