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In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

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Abstract

We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.

Graphical abstract: In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

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Publication details

The article was received on 16 May 2018, accepted on 21 Jul 2018 and first published on 30 Jul 2018


Article type: Communication
DOI: 10.1039/C8AN00913A
Citation: Analyst, 2018, Advance Article
  • Open access: Creative Commons BY-NC license
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    In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

    O. Jonas, J. W. Kang, S. P. Singh, A. Lammers, F. T. Nguyen, R. R. Dasari, P. T. C. So, R. Langer and M. J. Cima, Analyst, 2018, Advance Article , DOI: 10.1039/C8AN00913A

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