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Glutathione-driven Cu(I)–O2 chemistry: a new light-up fluorescent assay for intracellular glutathione

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Abstract

Besides its widely known role as an endogenous antioxidant in scavenging free radicals, glutathione (GSH) can also play the role of prooxidant and promote CuO-induced formation of hydroxyl radicals to light up a fluorescent signal through Cu(I)–O2 chemistry without requiring additional H2O2. This approach is independent of the mechanisms of enzyme mimics, such as the well-known oxidase and peroxidase mimetics, providing a new method to simply and effectively analyze intracellular GSH.

Graphical abstract: Glutathione-driven Cu(i)–O2 chemistry: a new light-up fluorescent assay for intracellular glutathione

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Publication details

The article was received on 16 Apr 2018, accepted on 21 Apr 2018 and first published on 25 Apr 2018


Article type: Communication
DOI: 10.1039/C8AN00704G
Citation: Analyst, 2018, Advance Article
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    Glutathione-driven Cu(I)–O2 chemistry: a new light-up fluorescent assay for intracellular glutathione

    P. F. Gao, Y. T. Mao, T. Yang, H. Y. Zou, Y. F. Li and C. Z. Huang, Analyst, 2018, Advance Article , DOI: 10.1039/C8AN00704G

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