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Issue 10, 2018
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Colorimetric sensor for cimetidine detection in human urine based on D-xylose protected gold nanoparticles

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Abstract

Herein, a simple, novel, and rapid colorimetric sensor for cimetidine (Cim) detection based on D-xylose protected gold nanoparticles (D-x@AuNPs) has been developed for the first time. The D-x@AuNPs were characterized by UV-vis, TEM and FT-IR techniques. Cimetidine causes the aggregation of D-x@AuNPs due to the formation of a strong covalent Au–N bond and electrostatic binding. As the cimetidine concentration increased, the color of the solutions gradually changed from wine-red to blue, and the large absorption band shifted from 533 to 680 nm upon D-x@AuNP aggregation. The effects of different experimental parameters were investigated. A comparative study on the detection of Cim using citrated capped AuNPs and D-x@AuNPs was presented. Under optimum conditions, the UV-vis spectra showed that the absorption ratio (A680/A533) increased linearly with the concentration of cimetidine in the range of 7 × 10−8 to 3 × 10−6 M with a correlation coefficient of 0.9956 and a limit of detection of 1 × 10−8 M without needing any complicated instruments. The selectivity of the D-x@AuNP detection system for cimetidine was excellent when compared with other ions and analytes. Due to their rapid and visible color changes, and their remarkable selectivity, the D-x@AuNPs synthesized in this study were suitable and could be applied to the detection of cimetidine in human urine.

Graphical abstract: Colorimetric sensor for cimetidine detection in human urine based on d-xylose protected gold nanoparticles

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Publication details

The article was received on 17 Mar 2018, accepted on 11 Apr 2018 and first published on 19 Apr 2018


Article type: Paper
DOI: 10.1039/C8AN00499D
Citation: Analyst, 2018,143, 2369-2376
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    Colorimetric sensor for cimetidine detection in human urine based on D-xylose protected gold nanoparticles

    F. Hu, P. Wu, R. Wang, W. Liu and H. He, Analyst, 2018, 143, 2369
    DOI: 10.1039/C8AN00499D

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