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Issue 10, 2018
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A fluorescent probe based on a Tb3+/Cu2+ co-functionalized MOF for urinary sarcosine detection

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Abstract

A novel luminescent probe based on a Tb3+/Cu2+ heterometallic metal–organic framework (MOF) was first designed for beamed monitoring of urinary sarcosine, a differential metabolite that can indicate the progression of prostate cancer (PCa). The fluorescent probe presented high selectivity towards sarcosine in urine. It also displayed good sensitivity with a comparatively low detection limit and a fast response to sarcosine within 5 min. Moreover, such high selectivity and sensitivity towards sarcosine is not subject to interference from other coexisting species in urine. At the same time, this fluorescent material also demonstrated the possibility for recycling. The excellent sensing performance of this Ln-MOF (lanthanide MOF) enables it to be further employed as a serviceable tool for PCa diagnosis and monitoring.

Graphical abstract: A fluorescent probe based on a Tb3+/Cu2+ co-functionalized MOF for urinary sarcosine detection

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Publication details

The article was received on 07 Mar 2018, accepted on 03 Apr 2018 and first published on 04 Apr 2018


Article type: Paper
DOI: 10.1039/C8AN00425K
Citation: Analyst, 2018,143, 2349-2355
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    A fluorescent probe based on a Tb3+/Cu2+ co-functionalized MOF for urinary sarcosine detection

    N. Sun and B. Yan, Analyst, 2018, 143, 2349
    DOI: 10.1039/C8AN00425K

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