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Exploiting the conformational-selection mechanism to control the response kinetics of a “smart” DNA hydrogel

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Abstract

The sequence-specific hybridization and molecular recognition properties of DNA support the construction of stimulus-responsive hydrogels with precisely controlled crosslink geometry. Here we show that, as predicted by the conformational selection mechanism, the response kinetics of such a hydrogel can be tuned over orders of magnitude by modulating the thermodynamic stability of its crosslinks.

Graphical abstract: Exploiting the conformational-selection mechanism to control the response kinetics of a “smart” DNA hydrogel

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Publication details

The article was received on 21 Feb 2018, accepted on 15 Apr 2018 and first published on 24 Apr 2018


Article type: Paper
DOI: 10.1039/C8AN00337H
Citation: Analyst, 2018, Advance Article
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    Exploiting the conformational-selection mechanism to control the response kinetics of a “smart” DNA hydrogel

    A. J. Simon, L. T. Walls-Smith and K. W. Plaxco, Analyst, 2018, Advance Article , DOI: 10.1039/C8AN00337H

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