Issue 11, 2018

Exploiting the conformational-selection mechanism to control the response kinetics of a “smart” DNA hydrogel

Abstract

The sequence-specific hybridization and molecular recognition properties of DNA support the construction of stimulus-responsive hydrogels with precisely controlled crosslink geometry. Here we show that, as predicted by the conformational selection mechanism, the response kinetics of such a hydrogel can be tuned over orders of magnitude by modulating the thermodynamic stability of its crosslinks.

Graphical abstract: Exploiting the conformational-selection mechanism to control the response kinetics of a “smart” DNA hydrogel

Supplementary files

Article information

Article type
Paper
Submitted
21 Feb 2018
Accepted
15 Apr 2018
First published
24 Apr 2018

Analyst, 2018,143, 2531-2538

Author version available

Exploiting the conformational-selection mechanism to control the response kinetics of a “smart” DNA hydrogel

A. J. Simon, L. T. Walls-Smith and K. W. Plaxco, Analyst, 2018, 143, 2531 DOI: 10.1039/C8AN00337H

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